Epigenetics Development and Disease [Hardcover]

Epigenetics fine-tunes the life processes dictated by DNA sequences, but also kick-starts pathophysiological processes including diabetes, AIDS and cancer. This volume tracks the latest research on epigenetics, including work on new-generation therapeutics.

PART I: EPIGENETICS AND EVOLUTION.- 1.1 Chromatin Organization, Epigenetics and Differentiation: An evolutionary perspective.- 1.2 Secondary structures of the core histone N-terminal tails: their role in regulating chromatin structure.- 1.3 Megabase replication domains along the human genome: Relation to chromatin structure and genome organization.- 1.4 Role of DNA methyltransferases in epigenetic regulation in bacteria.- PART II: DEVELOPMENTAL EPIGENETICS.- 2.1 Metabolic aspects of epigenome: Coupling of S-adenosylmethionine synthesis and gene regulation on chromatin by SAMIT module.- 2.2 Epigenetic regulation of male germ cell differentiation.- 2.3 Epigenetic Regulation of Skeletal Muscle Development and Differentiation.- 2.4 Small changes, big effects: chromatin goes aging.- 2.5 Homeotic gene regulation: A paradigm for epigenetic mechanisms underlying organismal development.- PART III: EPIGENETICS AND TRANSCRIPTION REGULATION.- 3.1 Basic mechanisms in RNA Polymerase I transcription of the ribosomal RNA genes.- 3.2 The RNA polymerase II transcriptional machinery and its epigenetic context.- 3.3RNA polymerase III transcriptions - regulated by chromatin structure and regulator of nuclear chromatin organization.- 3.4. The Role of DNA Methylation and Histone Modifications in Transcriptional Regulation in humans.- 3.5 Histone variants and Transcription regulation.- 3.6Noncoding RNAs in Chromatin Organization and Transcription Regulation: An Epigenetic View.- 3.7 Chromatin structure and organization: the relation with gene expression during development and disease.- PART IV: EPIGENETICS AND DISEASE.- 4.1 Epigenetics and cancer: Development, Differentiation and Pathobiology.- 4.2 Epigenetic Regulatló