Role of Capsaicin in Oxidative Stress and Cancer [Hardcover]

This book describes the mechanism of the anti-cancer effects of capsaicin including the involvement of cytochrome P-450 in the bioactivation; identification of mitochondria as the key target site for oxidative stress; involvement of mitochondrial respiratory chain in the production of ROS; prevention of chemically-induced carcinogenesis, discussion on TRPV-1 receptor mediated or independent anti-cancer effects; identification of p53 activation as a possible mechanism; involvement of Cox-2 in apoptosis, suppression of transcription factors such as NF-kB and STAT-3; inhibition of cell survival pathways including PI3K/Akt and the involvement of intrinsic mitochondrial cell death pathway.

Preface.-?Role of capsaicin in cancer prevention.-?Role of death receptors belonging to the TNF family in capsaicin-induced apoptosis of tumor cells.-?Role of capsaicin in prostate cancer.-?Capsaicin and the urinary bladder.-?Inhibition of pancreatitis and carcinogenesis by capsaicin.-?Cytochrome P450-dependent modification of capsaicinoids:? pharmacological inactivation and bioactivation mechanisms.-?The cancer suppressing and promoting actions of capsaicin.-?Oxidative stress by capsaicin in cancer.

Capsaicin is a principal pungent ingredient of red chili peppers, first isolated in the early nineteenth century by Christian Friedrich Bucholz. Widely consumed as a spice in South Asia and Latin America, Capsaicin has been used to treat pain and inflammation associated with a variety of diseases, including rheumatoid arthritis, diabetic neuropathy, post-masectomy pain, cluster headaches, and herpes zoster. Although recent studies have evaluated capsaicin as a novel anti-cancer agent, and mechanisms of capsaicin in preventing cancer have been described sporadically, the literature lacks a comprehensive review of capsaicin as a chemo-preventive agent.

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