This concise handbook provides an overview of incretin-based therapies and guidance for incorporating them into the treatment of type 2 diabetes. Chapters include landmark clinical trials and international treatment guidelines in order to update readers with all major advances in the field. An ideal resource for medical professionals that treat patients with type 2 diabetes in hospital and clinical settings.
1. Introduction and disease overview
References
2. Incretin hormones as a target for therapy
Incretin hormone physiology
The incretin-producing cell
GIP and GLP-1 action
Measurement of the incretin hormones
Incretin action in healthy individuals
Incretin action in patients with type 2 diabetes
Therapeutics application
References
3. Glucagon-like peptide receptor agonists
Introduction
GLP-1 receptor agonists
Extrapancreatic effects GLP-1 receptor agonists
Pancreatic safety
Perspectives
References
4. Dipeptidyl peptidase-4 inhibitors
Introduction
Pharmacokinetics and pharmacodynamics
Efficacy
Combination therapy
Use in specific patient populations
Conclusions
References
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