Cyclic Peptide Design [Hardcover]

This book covers strategies to improve cell permeability, intestinal permeability, and metabolic stability, which are the typical liabilities associated with cyclic peptides, to enhance protein-protein recognition, and to build upon natures cyclic peptides and macrocycles. Chapters also cover key peptide screening and display strategies, as well as important synthetic approaches towards cyclic and helical peptides. Cyclic peptides have become of significant importance as chemical tools in biology and drug discovery, since this class of chemicals has become a credible alternative source of new drug leads on par with traditional small molecules. As a part of the Methods in Molecular Biology series, this collection includes the kind of detail and implementation advice to aid researchers in the field. Design Principles for Intestinal Permeability of Cyclic Peptides.- Strategies to Enhance Metabolic Stabilities.- Designing Cell-Permeable Macrocyclic Peptides.- Computational Methods for Studying Conformational Behaviors of Cyclic Peptides.- Computational Opportunities and Challenges in Finding Cyclic Peptide Modulators of Protein-Protein Interactions.- Design of Cyclic Peptides as Protein Recognition Motifs.- Design and Synthetic Strategies for Helical Peptides.- Click Chemistry for Cyclic Peptides Drug Design.- Frontier between Cyclic Peptides and Macrocycles.- Building upon Natures Framework: Overview of Key Strategies towards Increasing Drug-Like Properties of Natural Product Cyclopeptides and Macrocycles.- Design of Oxytocin Analogs.- DNA-Encoded Macrocyclic Peptide Library.- Peptide Display Technologil#%