The Naphthyridines [Hardcover]

A volume in the Chemistry of Heterocyclic Compounds series, this book provides a summary of the chemistry of each of the six naphthyridine systems along with tables of known simple derivatives with original references.
Each of the six naphthyridine systems are described in valuable detail and coverage includes: Primary synthetic methods from non-naphthyridine substrates; Chemistry and properties of the parent heterocycle and its simple alkyl derivatives; Formation and reactions of halogeno derivatives; formation and reactions of hydroxy, oxo, alkoxy, and related derivatives.

Chapter 1 Primary Syntheses of 1,5-Naphthyridines 1

1.1 From a Single Aliphatic Substrate 1

1.2 From a Single Pyridine Substrate 2

1.2.1 By Formation of the N1,C2-Bond 2

1.2.2 By Formation of the C3,C4-Bond 3

1.2.3 By Formation of the C4,C4a-Bond 4

1.3 From a Pyridine Substrate with One Synthon 5

1.3.1 Where the Synthon Supplies One Atom 5

1.3.2 Where the Synthon Supplies Two Atoms 6

1.3.3 Where the Synthon Supplies Three Atoms 7

1.4 From a Pyridine Substrate and Two Synthons 9

1.5 From Other Heterocyclic Substrates 10

Chapter 2 1,5-Naphthyridine, Alkyl-1,5-Naphthyridines, and Aryl-1,5-Naphthyridines 13

2.1 1,5-Naphthyridine 13

2.1.1 Preparation of 1,5-Naphthyridine 13

2.1.2 Properties of 1,5-Naphthyridine 14

2.1.3 Reactions of 1,5-Naphthyridine 16

2.2 Alkyl- and Aryl-1,5-Naphthyridines 19

2.2.1 Preparation of Alkyl- and Aryl-1,5-Naphthyridines 20

2.2.2 Reactions of Alkyl- and Aryl-1,5-Naphthyridines 22

Chapter 3 Halogeno-1,5-Naphthyridines 25