Repeated Measurements and Cross-Over Designs [Hardcover]

An introduction to state-of-the-art experimental design approaches to better understand and interpret repeated measurement data in cross-over designs.

Repeated Measurements and Cross-Over Designs:

• Features the close tie between the design, analysis, and presentation of results
• Presents principles and rules that apply very generally to most areas of research, such as clinical trials, agricultural investigations, industrial procedures, quality control procedures, and epidemiological studies
• Includes many practical examples, such as PK/PD studies in the pharmaceutical industry, k-sample and one sample repeated measurement designs for psychological studies, and ?residual effects of different treatments in controlling conditions such as asthma, blood pressure, and diabetes.
• Utilizes SAS(R) software to draw necessary inferences.? All SAS output and data sets are available via the book's related website.

This book is ideal for a broad audience including statisticians in pre-clinical research, researchers in psychology, sociology, politics, marketing, and engineering.?

Preface xi

1. Introduction 1

1.1 Introduction 1

1.2 One-Sample RMD 2

1.3 k-Sample RMD 4

1.4 Split-Plot Designs 7

1.5 Growth Curves 13

1.6 Cross-Over Designs 14

1.7 Two-Period Cross-Over Designs 18

1.8 Modifications in Cross-Over Designs 19

1.9 Nonparametric Methods 22

References 23

2. One-Sample Repeated Measurement Designs 25

2.1 Introduction 25

2.2 Testing for Sphericity Condition 26&lF