Interpretation of MS-MS Mass Spectra of Drugs and Pesticides [Hardcover]

Provides comprehensive coverage of the interpretation of LCMSMS mass spectra of 1300 drugs and pesticides

• Provides a general discussion on the fragmentation of even-electron ions (protonated and deprotonated molecules) in both positive-ion and negative-ion modes ?
• This is the reference book for the interpretation of MSMS mass spectra of small organic molecules?
• Covers related therapeutic classes of compounds such as drugs for cardiovascular diseases, psychotropic compounds, drugs of abuse and designer drugs, antimicrobials, among many others
• Covers general fragmentation rule as well as specific fragmentation pathways for many chemical functional groups
• Gives an introduction to MS technology, mass spectral terminology, information contained in mass spectra, and to the identification strategies used for different types of unknowns

Preface xi

Abbreviations xiii

1 Introduction to LC-MS Technology 1

1.1 Introduction 2

1.2 Analyte Ionization: Ion Sources 3

1.2.1 Electron Ionization 3

1.2.2 Chemical Ionization 7

1.2.3 Atmospheric-Pressure Ionization 13

1.2.4 Electrospray Ionization 16

1.2.5 Atmospheric-Pressure Chemical Ionization and Photoionization 20

1.2.6 Other Ionization Techniques 26

1.3 Mass Spectrometer Building Blocks 28

1.3.1 Introduction 28

1.3.2 Quadrupole Mass Analyzer 32

1.3.3 Ion-Trap Mass Analyzer 33

1.3.4 Time-of-Flight Mass Analyzer 34

1.3.5 Orbitrap Mass Analyzer 35

1.3.6 Other Mass Analyzers 36

1.4 Tandem Mass Spectrometry 37