This book presents an overview of the current state of research on ultrashort electric field pulses of high intensity and their use in biology and medicine. It examines in detail the most recent and exciting advances in how nanosecond and picosecond electric pulse research has grown and expanded into new areas of biology and medicine.
Further, the book specifically focuses on electric pulses in the time domain, on intracellular effects as opposed to plasma membrane electroporation, and highlights the biological and medical applications of these unique pulse effects. Since the authors were initial innovators exploring nanosecond and picosecond pulses, their unique perspectives foreshadowed directions the research took, expanding into new areas that they continue to investigate today.
Introduction History and Fundamentals.- From Milliseconds to Picoseconds effects on cell membranes.- Simulations of membrane effects.- Pulsed power systems and Pulse Delivery Systems.- Experimental studies.- Thermal assistance.
Stephen J. Beebe studied Zoology at Ohio University, Athens. He then served as a Peace Corps Volunteer in the British West Indies (19731975) teaching biology, working on soil and water conservation with 4H and diagnostic biochemistry and analysing the nutritional status of preschool children at Queen Elizabeth Hospital. As a PhD student, he purified and characterized cAMP-independent protein kinases involved in glycogen metabolism. As a Post-Doctoral Fellow and Research Associate at the Howard Hughes Medical Institute (HHMI) in Vanderbilt, he defined the roles for cAMP-dependent protein kinases (PKAs) and cAMP phosphodiesterases in regulating glycogen and lipid metabolism, insulin action, gene transcription and granulosa cell differentiation.
As a Fulbright and Marshal Scholar in Oslo, he cloned three catalytic subunits l“i
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