Anticholinesterase Pesticides: Metabolism, Neurotoxicity, and Epidemiology [Hardcover]

This book offers an important reference source about the most common classes of pesticides for researchers engaged in the area of neurotoxicology, metabolism, and epidemiology. The book presents details about thorough characterization of target and non-target enzymes and proteins involved in toxicity and metabolism; and epidemiology of poisonings and fatalities in people from short- and long- term exposures to these pesticides in different occupational settings on an individual country basis as well as on a global basis. The early portion of the book deals with metabolism, mechanisms and biomonitoring of anticholinesterase pesticides, while the later part deals with epidemiological studies, regulatory issues, and therapeutic intervention.Foreword (Donald J. Ecobichon).

Section I.

1. Introduction (Tetsuo Satoh, Ramesh C. Gupta).

Section II: Metabolism and Mechanisms.

2. ACETYLCHOLINESTERASE AND ACETYLCHOLINE RECEPTORS: BRAIN REGIONAL HETEROGENEITY (Haruo Kobayashi, Tadahiko Suzuki, Fumiaki Akahori and Tetsuo Satoh).

3. GENOMIC IMPLICATIONS OF ANTICHOLINESTERASE SENSITIVITIES (Jonathan E. Cohen, Gabrial Zimmermann, Alon Friedman and Hermona Soreq).

4. BUTYRYLCHOLINESTERASE: OVERVIEW, STRUCTURE AND FUNCTION (Oksana Lockridge, Ellen G. Duysen and Patrick Masson).

5.CARBOXYLESTERASES:OVERVIEW, STRUCTURE, FUNCTION AND POLYMORPHISM (Masakiyo Hosokawa and Tetsuo Satoh).

6. CARBOXYLESTERASES IN THE METABOLISM AND TOXICITY OF PESTICIDES (Colin J. Jackson, Juan Sanchez-Hernandez, Craig E. Wheelock and John G. Oakeshott).

7. THE METABOLIC ACTIVATION AND DETOXICATION OF ANTICHOLINESTERASE INSECTICIDES (Janice E. Chambers, Edward C. Meek and Mal3G