The Retinoids: Biology, Biochemistry, and Disease [Hardcover]

The Retinoids: Biology, Biochemistry, and Disease?provides an overview and synthesis of the retinoid molecules, from basic biology to mechanisms of diseases and therapy. Divided into five sections, the book covers retinoic acid signaling from biochemical, genetic, developmental, and clinical perspectives.?

The text is divided into five sections, the first of which examines vitamin A metabolic and enzymatic pathways. Focus then shifts to the role of retinoic acid signaling in development, and then to retinoids and physiological function. The book concludes with chapters on retinoids, disease and therapy.

Comprehensive in scope and written by leading researchers in the field,?The Retinoids: Biology, Biochemistry, and Disease?will be an essential reference for biologists, biochemists, geneticists and developmental biologists, as well as for clinicians and pharmacists engaged in clinical research involving retinoids.

Contributors ix

Preface xiii

Part I: Vitamin A metabolic and enzymatic pathways 1

1 Vitamin a Metabolism, Storage and Tissue Delivery Mechanisms 3
William S. Blaner and Yang Li

2 Assimilation and Conversion of Dietary Vitamin a into Bioactive Retinoids 35
Earl H. Harrison and Carlo dela Sen?s

3 Intracellular Storage and Metabolic Activation of Retinoids: Lipid Droplets 57
Joseph L. Napoli and Charles R. Krois

4 Evolution of the Retinoic Acid Signaling Pathway 75
Vincent Laudet, Elisabeth Zieger, and Michael Schubert

Part II: Biochemistry and cellular biology of retinoic acid signaling 91

5 Control of Gene Expression by Nuclear Retinoic Acil3&