Carcinogenesis: Fundamental Mechanisms and Environmental Effects: Proceedings of the Thirteenth Jerusalem Symposium on Quantum Chemistry and Biochemis [Paperback]

Carcinogenicity of Polycyclic Aromatic Hydrocarbons: The Bay-Region Theory.- Inactivation of ?X174 and SV 40 Viral DNA Replication by Diol Epoxide Derivatives of Carcinogenic Polycyclic Hydro-carbons.- Dihydrodiols and Diol-Epoxides in the Activation and Detoxification of Polycyclic Hydrocarbons.- Metabolically Generated Free Radicals from Many Types of Chemical Carcinogens and Binding of the Radicals with Nucleic Acid Bases.- Nucleophilicity of DNA. Relation to Chemical Carcinogenesis.- An Analysis of the Reactivities of Epoxide Rings in Some Cyclic Hydrocarbons.- Biological Effects of Specific Hydrocarbon-DNA Reactions.- The Effect of Base Modification on Fidelity in Transcription.- Modification of DNA by Carcinogenic Aromatic Amines In Vivo and In Vitro with Possible Promutagenic Consequences.- Bio-chemical Considerations of the Enzymology Associated with Quinone and Tetrol Formation During Benzo (a) pyrene Metabolism.- Stereochemical Aspects of Benzo (a) pyrene Metabolism and Biochemical Individuality in Human Cells.- Metabolic and Structural Requirements for the Carcinogenic Potencies of Unsubstituted and Methyl-Substituted Polycyclic Aromatic Hydrocarbons.- Formation and Inactivation of DNA-Binding Metabolites of Benzo (a) pyrene Studied with Isolated Cells and Subcellular Fractions.- Enzymic Control of Reactive Metabolites from Aromatic Carcinogens.- Aflatoxin-DNA Interactions: Qualitative, Quantitative and Kinetic Features in Relation to Carcinogenesis.- Structural Modifications and Specific Recognition by Antibodies of Carcinogenic Aromatic Amines Bound to DNA.- Immunological Detection and Quantification of DNA Components Structurally Modified by Alkylating Carcinogens (Ethylnitrosourea)..- Characteristics of Stages of Hepatocarcinogenesis.- Mechanisms ofGenetic Susceptibility to Cancer.- Constitutive Uncoupling of Pathways of Gene Expression that Control Growth and Differentiation and the Molecular Mechanism of Carcinogenesis.- Amplification of Carcinogenel