Hardware/Software Co-Design and Optimization for Cyberphysical Integration in Digital Microfluidic Biochips [Hardcover]

This book describes a comprehensive framework for hardware/software co-design, optimization, and use of robust, low-cost, and cyberphysical digital microfluidic systems. Readers with a background in electronic design automation will find this book to be a valuable reference for leveraging conventional VLSI CAD techniques for emerging technologies, e.g., biochips or bioMEMS. Readers from the circuit/system design community will benefit from methods presented to extend design and testing techniques from microelectronics to mixed-technology microsystems. For readers from the microfluidics domain, this book presents a new design and development strategy for cyberphysical microfluidics-based biochips suitable for large-scale bioassay applications.

Takes a transformative, cyberphysical approach towards achieving closed-loop and sensor feedback-driven biochip operation under program control;
Presents a physically-aware system reconfiguration technique that uses sensor data at intermediate checkpoints to dynamically reconfigure biochips;
Enables readers to simplify the structure of biochips, while facilitating the general-purpose use of digital microfluidic biochips for a wider range of applications.

Introduction.- Error-Recovery in Cyberphysical Biochips.- Real-Time Error Recovery Using a Compact Dictionary.- Biochemistry Synthesis under Completion-Time Uncertainties in Fluidic Operations.- Optimization of On-Chip Polymerase Chain Reaction.- Pin-Count Minimization for Application-Independent Chips.- Pro-Limited Cyberphysical Microfluidic Biochip.- Conclusions.

Yan Luo received the Bachelor degree from Tsinghua University,Beijing, in 2010, and the Master and Ph.D. degrees from Duke University in North Carolina, in 2012 and 2013, respectively. Dr.Luo's research interests include hardware/software co-design for cyber-physical system, engineering data analysis and design/implementationlsa