Specific Gene Expression and Epigenetics: The Interplay Between the Genome and Its Environment [Hardcover]

This title includes a number of Open Access chapters.

This new volume on gene expression and epigenetics discusses environmental effects related to specific gene expression. The book also shows methods for bioinformatic analysis of the epigenome. The book is broken into two sections: the first looks at eukaryotic DNA methylation and the second addresses how to integrate genomic medicine into clinical practice.

The book includes chapters on these topics:

Gene expression in colon cancer tissue

Epigenetics in human acute kidney injury

Embryologically relevant candidate genes in MRKH patients

DNA methylation in common skeletal disorders

Causal relationships in genomics

Predicting severe asthma exacerbations in children

Epigenetic understanding of gene-environment interactions in psychiatric disorders

Introduction. Part I: Eukaryotic DNA Methylation. Renal Kallikrein Excretion and Epigenetics in Human Acute Kidney Injury: Expression, Mechanisms and Consequences. COX-2 Gene Expression in Colon Cancer Tissue Related to Regulating Factors and Promoter Methylation Status. Down-Regulation of Promoter Methylation Level of CD4 Gene After MDV Infection in MD-Susceptible Chicken Line. A Combination of Transcriptome and Methylation Analyses Reveals Embryologically Relevant Candidate Genes in MRKH Patients. The Role of DNA Methylation in Common Skeletal Disorders. Enrichment-Based DNA Methylation Analysis Using Next-Generation Sequencing: Sample Exclusion, Estimating Changes in Global Methylation, and the Contribution of Replicate Lanes. Part II: Integrating Genomic Medicine into the Clinical Practice. Assessing Causal Relationships in Genomics: From Bradford-Hill Criteria to Complex Gene-Environment Interlƒ­