From the 15th century, and especially after the Union of the Churches in1439 and the fall of Constantinople in 1453, the island of Crete wasconsidered both by the pope and by Cardinal Bessarion as the ideal placefor the spread of the new philo-Catholic reality. This is also theperiod during which Crete provided the West with scholars, scribes andtexts, giving a substantial boost to the Greek-knowledge aspect ofItalian humanism. Through an interdisciplinary approach involvingarchival documents in Latin and manuscript evidences in Greek, thisstudy aims to portray the Uniate Cretan scribe and theologian JohnPlousiadenos (1423?-1500) and to explore the political, religious andintellectual context within which he lived and acted. The appendix ofthis book includes, among other materials, the editio princeps of twoGreek texts (the <i>Prayer to the Holy Spirit</i> and the <i>Pattern forthe Catholic confession</i>) composed by John Plousiadenos.