Handbook of Pharmacokinetics and Toxicokinetics [Paperback]

Chapter 1. Pharmacokinetics and Toxicokinetics. Chapter 2. PK-TK Conisderations of Auricular (Optic) - Buccal/Sublingual and Ocular/Ophthalmic Routes of Administration. Chapter 3. PK-TK Considerations of Nasal, Pulmonary and Oral Routes of Administration. Chapter 4. PK-TK Considerations of Intraarterial - Intramuscular Intraperitoneal - Intravenous - and Subcutaneous Routes of Administration. Chapter 5. PK-TK Considerations of Transdermal - Intradermal - and Intraepidermal Routes of Administration. Chapter 6. PK-TK Considerations of Rectal - Vaginal - Intraovarian Routes of Administration. Chapter 7. PK-TK Considerations of Absorption Mechanisms and Rate Equations. Chapter 8. PK-TK Considerations of Distribution Mechanisms and Rate Equations. Chapter 8. PK-TK Considerations of Metabolism Biotransformation of Xenobiotics Mechanisms and Rate Equations. Chapter 10. PK-TK Considerations of Renal Function and Elimination of Xenobiotics Estimation of Parameters and Constants. Chapter 11. Elimination Rates & Clearances (Excretion + Metabolism). Chapter 12. Approaches in PK-PD and TK-TD Mathematical Modeling. Chapter 13. Practical Applications of PK/TK Models Instantaneous Exposure to Xenobiotics Single Intravenous Bolus Injection. Chapter 14. Practical Applications of PK/TK Models Continuous Zero-Order Exposure to Xenobiotics Intravenous Infusion. Chapter 15. Practical Applications of PK/TK Models First-order Absorption via Extravascular Routes Oral Administration. Chapter 16. Practical Application of PK/TK Models Multiple Dosing Kinetics. Chapter 17. Biopharmaceutics Provisions, Dynamics, and Classifications Mechanistic Absorption Models. Chapter 18. Bioavailability, Bioequivalence and Biosimilarity. Chapter 19. Quantitative Extrapolations Cross-Species Extrapolation Low-Dose Extrapolation. Chapter 20. Practical Application of PK/TK Models Population Pharmacokinetics/Toxicokinetics. Chapter 21. Practical Application of PK/TK Models Preclinical PK/TK and Clƒt