Textbook of Ion Channels Volume I: Fundamental Mechanisms and Methodologies [Paperback]

Part I: Fundamental Mechanisms  1. Ion Selectivity and Conductance  2. Voltage-Dependent Gating of Ion Channels  3. Ligand-Dependent Gating Mechanism  4. Mechanosensitive Channels and Their Emerging Gating Mechanisms  5. Inactivation and Desensitization  6. Ion Channel Inhibitors  Part II: Methodologies  7. Expression of Channels in Heterologous Systems and Voltage Clamp Recordings of Macroscopic Currents  8. Patch Clamping and Single-Channel Analysis  9. Patch Clamp Recordings from Native Cells and Isolation of Membrane Currents  10. Models of Ion Channel Gating  11. Investigating Ion Channel Structure and Dynamics Using Fluorescence Spectroscopy  12. Ion Channel Structural Biology in the Era of Single Particle Cryo-EM  13. Protein Crystallography  14. Rosetta Structural Modeling  15. Molecular Dynamics  16. Genetic Models and Transgenics  17. EPR and DEER Spectroscopy

The Textbook of Ion Channels is a set of three volumes providing a wide-ranging reference source on ion channels for students, instructors and researchers. Ion channels are membrane proteins that control the electrical properties of neurons and cardiac cells; mediate the detection and response to sensory stimuli like light, sound, odor, and taste; and regulate the response to physical stimuli like temperature and pressure. In non-excitable tissues, ion channels are instrumental for the regulation of basic salt balance that is critical for homeostasis. Ion channels are located at the surface membrane of cells, giving them the unique ability to communicate with the environment, as well as the membrane of intracellular organelles, allowing them to regulate internal homeostasis. Ion channels are fundamentally important for human healtl“Ý