Cryo-Electron Microscopy in Structural Biology: From Structural Insights to Tomography and Drug Discovery [Hardcover]

Cryo-Electron Microscopy, in combination with Tomography, has emerged as a new technology for visualizing molecular structures revealing the native molecular details of membranes, viruses, and cells. This comprehensive, volume brings together authoritative overviews of these methods from structural and biological perspective.

Editor

List of contributors

Foreword

Preface

SECTION I Cryo-EM in Cell Biology: Structure Determination of Protein Assemblies and Cellular Organelle

Chapter 1 Introduction on Cryogenic Electron Microscopy in Structural Biology

Krishnarao Appasani

Chapter 2 Structural Dynamics of Proteasome Regulation by Cryo-EM

Youdong Mao

Chapter 3 Cryo-EM Structures of a Ubiquitin-Specific Protease in Complex with Substrate

Martin Rennie

Chapter 4 Structural Biology of Protein Kinases and Their Regulation

Samrat Mitra, Pranita Ray, Prateeka Borar, and Smarajit Polley

Chapter 5 The Life and Times of p53: Structural Advancements to Decipher the Guardian of the Genome

Maria J. Solares, Samantha Berry, and Deborah F. Kelly

SECTION II Technology Platform and Evolving Technologies

Chapter 6 Single-Particle Cryo-EM: What Happens Inside the Black Box?

Sayan Bhakta and Marin van Heel

Chapter 7 Streptavidin Affinity Grids in the Study of MalÓ6