Handbook of Statistics in Clinical Oncology [Hardcover]

SECTION 1?Cancer Prevention & Screening

Chapter 1?Cancer Screening Trials

Chapter 2?Cancer Risk Prediction Models

Chapter 3?Incorporating External Registry Data Into Cohort-based Cancer Risk Prediction Tools

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SECTION 2?Trial Design | Early-Phase Trials

Chapter 4?Phase I  Overview and Recent Trial Designs

Chapter 5?Statistical and Machine Learning Methods for Phase I Dose-Finding

Chapter 6?Seamless Phase I/II Trial Design for Assessing Toxicity and Efficacy?for Targeted Agents

Chapter 7?Designs Using Time to Event Endpoints / Single Arm versus Randomized Phase II Designs

Chapter 8?Phase II Selection Designs

Chapter 9?Phase II Trials with Multiple Strata

SECTION 3?Trial Design | Late-Phase Trials

Chapter 10?Cure Rate Survival Models

Chapter 11 Phase III Trials for Targeted Agents

Chapter 12?Phase II and III Clinical Trial Designs for Precision Medicine

Chapter 13?SMARTs in Oncology

Chapter 14?Statistical Considerations in the Design and Analysis of Cancer Trials with Immune-Oncology Therapies

Chapter 15?Alpha Splitting

Chapter 16?Early Stopping of Clinical Trials Evaluating Targeted Therapies

Chapter 17?Noninferiority Trials

Chapter 18?Considerations for Pediatric Oncology Trials

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SECTION 4?Trial Conduct

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Chapter 19?An Overview of Master Protocols