Repeat Amino Acid Sequences in Proteins: Biochemical and Medical Consequences [Hardcover]

Preface. 1. Pathogenic Role of Repeat Polypeptides in Repeat Expansion Diseases. 2. Pathologies Due to PolyQ Sequences. 3. Importance of Surface Hydrophobic Clusters in Proteins. 4. Residue Cluster Classes in Protein-Protein Interactions. 5. Aromatic Clusters in Proteins: Folding, Drug Interactions and Protein-Protein Complexes. 6. Cell Penetrating Peptides with Repeat Sequences of Amino Acids. 7. Recent Advances and Applications in Self-Assembling Short-Chain Elastin-Like Peptide Analogs. 8. Unconventional Fluorescence Properties of Non-aromatic Amino Acids: Material and Biological Applications. Index.

Repeat amino acid sequences are important in protein structure, disorder, function and evolution. Repeats of some amino acids exist in proteomes across species.

This volume highlights:

• Which repeat sequences have pathogenic consequences and why?
• Repeats which lead to surface hydrophobic clusters and their importance
• Role of aromatic amino acid clusters in proteinprotein and proteindrug interactions
• Cellpenetrating peptides and Elastinlike peptides
• Unusual phenomenon of fluorescence observed with repeats of some nonaromatic amino acids
• The use of residue cluster classes to represent protein structure and model structurefunction relationships.

This volume highlights the use of residue cluster classes to represent proteins structure and model structure-function relationships. It explores the role of aromatic amino acid clusters in protein-protein and protein-drug interactions. It highlights the cell-penetrating peptides and Elastin-like peptide.

Vladimir N. Uversky B.S., M.S., Ph.D., D.Sc., Professor at the Department of Molecular Medicine, Morsani College of Medicine, Universitl“&