We have witnessed a rapid development within the field of the kidney and hypertension in diabetes mellitus. A significant amount of work within the traditional areas has been published, and several new dimensions are now being developed, mostly in the experimental setting. These dimensions are discussed in several chapters of this new edition, The Kidney and Hypertension in Diabetes Mellitus, FourthEdition. This volume endeavors to cover all aspects of renal involvement in diabetes. It is written by colleagues who are themselves active in the many fields of medical research covered in this volume: epidemiology, physiology and pathophysiology, laboratory methodology and renal pathology.Some Keys to the Literature. Prefaces. 1. Historical Aspects of Diabetes and Diabetic Renal Disease; T. Deckert. 2. The Nature of the Diabetic Glomerulus: Pressure-Induced and Metabolic Aberrations; P. Cortes, B.L. Riser. 3. Definition of Diabetic Renal Disease in Insulin-Dependent Diabetes mellitus Based on Renal Function Tests; C.E. Mogensen. 4. Retinopathy in Relation to Albuminuria and Blood Pressure in IDDM; N. Chaturvedi, J.H. Fuller. 5. Microalbuminuria and Cardivascular Disease; S.M. Thomas, G. Viberti. 6. The Heart in Diabetes: Results of Trials; G. Zuanetti, et al. 7. Albuminuria in Non-Insulin-Dependent Diabetes - Renal or Extra Renal Disease? A. Schmitz. 8. The Clinical Course of Renal Disease in Caucasian NIDDM-Patiens; S. Nielsen, A. Schmitz. 9. Use of Albumin/Creatinine Ratio in Patient Care and Clinical Studies; J.H. Warram, A. Krolewzki. 10. Serum Creatinine and Other Measures of GFR in Diabetes; P. Rossing. 11. Familial Factors in Diabetic Nephropathy; D.J. Petitt, et al. 12. Genetics and Diabetic Nephropathy; M. Marre, B. Bouhanick. 13. The Concept of Low Birth Weight and Renal Disease; J.R. Nyengaard, E. Vestbo. 14. Effect of Insulin on the Kidney and the Cardiovascular System; E.lcé