Lipid Mediators and Their Metabolism in the Brain [Hardcover]

Lipid Mediators and Their Metabolism in the Brain presents readers with cutting edge and comprehensive information not only on the synthesis and degradation of glycerophospholipid-, sphingolipid-, and cholesterol-derived lipid mediators, but also their involvement in neurological disorders. It is hoped that this monograph will be useful not only to postgraduate student and their teachers, but also to research scientists and physicians, who are curious about the generation and roles of lipid mediators in the brain.This book presents readers with comprehensive, cutting-edge information not only on the synthesis and degradation of glycerophospholipid-, sphingolipid-, and cholesterol-derived lipid mediators, but also their involvement in neurological disorders.

Chapter 1. Metabolism and roles of eicosanoids in brain.- Chapter 2. Recent Developments on the neurochemistry of docosanoids.- Chapter 3. Metabolism, roles, and involvement of lyso-glycerophospholipids in neurological disorders.- Chapter 4. Platelet activating factor in brain: its metabolism, roles and involvement in neurological disorders.- Chapter 5. Cannabinoids in the brain: their metabolism, roles, and involvement in neurological disorders.- Chapter 6. Neurochemical aspects of 4-hydroxynonenal.- Chapter 7. Isoprostanes and other non-enzymic polyunsaturated fatty acid-derived lipid mediators in the brain.- Chapter 8. Ceramide and ceramide 1-phosphate in the brain.- Chapter 9. Sphingosine and sphingosine 1 phosphate in brain.- Chapter 10. Cholesterol and hydroxycholesterol in the brain.- Chapter 11. Perspective and direction for future research on lipid mediators

Dr. Akhlaq A. Farooqui is a leader in the field of signal transduction, brain phospholipases A₂, bioactive ether lipid metabolism, polyunsaturated fatty acid metabolism, glycerophospholipid-, sphingolipid-, and cholesterol-derived lipid mediators, and glutamate-induced neurotoxicity.l#