Malaria Drugs, Disease and Post-genomic Biology [Hardcover]

Despite rapid increases in knowledge, malaria continues to kill more than a million people each year and causes symptomatic disease in a further 300 million individuals. This volume brings some of the world's best investigators to describe recent advances in both the scientific and clinical aspects of malaria, and bridges between the two.Despite rapid increases in knowledge, malaria continues to kill more than a million people each year and causes symptomatic disease in a further 300 million individuals. This volume brings some of the world's best investigators to describe recent advances in both the scientific and clinical aspects of malaria, and bridges between the two.Drugs and drug resistance.- Quinolines and Artemisinins: Chemistry, Biology and History.- Antimalarial multidrug resistance in Asia: mechanisms and assessment.- Antimalarial drug resistance in Africa: strategies for monitoring and deterrence.- Malaria the disease.- Uncomplicated malaria.- Metabolic complications of severe malaria.- The clinical and pathophysiological features of malarial anaemia.- Malaria in the pregnant woman.- Biology.- Host receptors in malaria merozoite invasion.- A post-genomic view of the mitochondrion in malarial parasites.- The plastid of Plasmodium spp. a target for inhibitors.- Hemoglobin degredation.- Bioavailable iron and heme metabolism in Plasmodium falciparum.- Plasmodium permiomics: membrane transport proteins in the malaria parasite.- Plasmodium ookinete invasion of the mosquito midgut.- Molecular genetics of the mosquito resistance to malaria parasites.- Functional proteome and expression analysis of sporozoites and hepatic stages of malaria development.- Subject index

This volume brings some of the worlds best investigators to describe recent advances in both the scientific and clinical aspects of malaria, and bridges between the two. The opening chapters discuss antimalarials and resistance to them in Africa and Asia. Then there are reviews of the differelcÂ