Mast Cell Biology Contemporary and Emerging Topics [Hardcover]

The editors of Mast Cell Biology, Drs. Gilfillan and Metcalfe, have enlisted an outstanding group of investigators to discuss the emerging concepts in mast cell biology with respect to development of these cells, their homeostasis, their activation, as well as their roles in maintaining health on the one hand and on the other, their participation in disease.

This book discusses emerging concepts in mast cell biology. It investigates development, homeostasis, activation of mast cells and their roles in maintaining health, on the one hand, and, on the other, their participation in disease.

Mast Cell Biology: Introduction And Overview.- Mast Cell Progenitor Trafficking And Maturation.- Monomeric IgE And Mast Cell Development, Survival And Function.- Mast Cell Apoptosis And Survival.- Regulators Of Ca²⁺ Signaling In Mast Cells: Potential Targets For Treatment Of Mast Cell-Related Diseases?.- Spatio-Temporal Signaling In Mast Cells.- The Mechanisms Of Exocytosis In Mast Cells.- An Emerging Role For The Lipid Mediator Sphingosine-1-Phosphate In Mast Cell Effector Function And Allergic Disease.- Down-Regulation Of Mast Cell Responses Through Itim Containing Inhibitory Receptors.- The Mast Cell In Innate And Adaptive Immunity.- Mast Cells And Immunoregulation/Immunomodulation.- Mast Cell Proteases As Protective And Inflammatory Mediators.- Mast Cells In Lung Inflammation.- Mast Cells, Angiogenes Is And Cancer

Alasdair Gilfillan, PhD received a BSc from the University of Strathclyde, Glasgow, Scotland and MSc and PhD degrees in Pharmacology from the University of Manchester, England. Following completion of his PhD, he moved to the United States to undertake research in Cell Biology and Biochemistry in the Department of Pediatrics, Yale University Medical School; initially as a Postdoctoral Fellow, then as an Associate Research Scientist. From there, Dr. Gilfillan moved to F. l#(