The mechanical behavior?of?biomedical materials and biological tissues are important for their proper function. This holds true, not only for?biomaterials?and tissues whose main function is structural such as skeletal tissues and their synthetic substitutes, but also for other tissues and?biomaterials. Moreover, there is an intimate relationship between?mechanics?and biology at different spatial and temporal scales. It is therefore important to study the mechanical behavior?of?both synthetic and livingbiomaterials. This Special Issue aims to serve as a forum for communicating the latest findings and trends in the study?of?the mechanical behavior?of?biomedical materials.