Mechanics of Breathing New Insights from New Technologies [Hardcover]

This book offers a state-of-the-art description of the complexity of the healthy and pathological respiratory system, with particular reference to the mechanics of the airways, lung and chest wall. Detailed information is provided on new insights into the mechanics of breathing that have been obtained through technological innovations in measurement systems, cutting-edge modeling techniques and novel approaches to functional imaging of the respiratory system. It is explained how these advances permit the assessment of emerging treatment approaches, including new drugs, innovative surgical techniques and modes of mechanical ventilation and new forms of rehabilitation. In order to ensure comprehensive coverage of the subject, the editor has assembled a multidisciplinary team of authors comprising basic scientists in respiratory medicine, chest and intensive care physicians and bioengineers involved in both modeling and instrumentation. The book is intended for intensive care physicians, respirologists, physiologists, rehabilitation specialists, basic scientists in respiration, research and clinical fellows, biomedical engineers involved with respiratory mechanics and respiratory therapists. They will update their knowledge and improve their clinical expertise.

Part I Physiological and Pathophysiological Aspects of Mechanics of Breathing.- 1 The Act of Breathing.- 2 The Work of Breathing During Exercise: Implication for Performance.- 3?Pathology of COPD and asthma.- 4 Pathophysiology of Airflow Obstruction.- 5 Role of airway Smooth Muscle Mechanical Properties in the Regulation of Airway Caliber.- 6 Nitric Oxide in Asthma?is like Insulin in Type II Diabetes.- 7 Static and Dynamic Hyperinflation in COPD.- 8 Lung Recruitment and Derecruitment.- Part II Assessment of Mechanics of Breathing.- 9 Pulmonary Function Testing: an Update.- 10 Oscillatory Mechanics.- 11 Chest Wall Mechanics and Opto-Electronic Plethysmography.- 12 Regional Blood Flow by NIRS and ICG.- 13 lC'