Mechanisms of Atrial Arrhythmias: Insights from the Development of a Biophysically Detailed Model of the Human Atria [Hardcover]

This thesis describes the development of biophysically detailed computer models of the human atria and torso to study the underlying mechanisms of cardiac diseases, some of the most common causes of morbidity and mortality. This is a cross-disciplinary project, involving fundamentals of cardiac electrophysiology, physics of excitable media, applied mathematics and high performance scientific computing and visualisation. The author uses computer models to provide insights into the underlying mechanisms of the genesis of atrial fibrillation and develops novel techniques for the monitoring of atrial tachycardia.Introduction.- Background.- Development of a new model for simulating the electrical action potentials of human atrial myocytes.- Development of a family of regional cell models.- Autonomic regulation and pathophysiological remodelling.- 3D Anatomical Modelling of the Atria.- Pacemaking and autonomic regulation in the 3D sinoatrial node and atria.- Atrial Fibrillation.- Discussion.This thesis describes the?development of biophysically detailed computer models of the human atria and torso to study the underlying mechanisms of cardiac diseases, some of the most common?causes of?morbidity and mortality. This is a cross-disciplinary project, involving fundamentals of cardiac electrophysiology, physics of excitable media, applied mathematics and high performance scientific computing and visualisation.? The author uses computer models to provide insights into the underlying mechanisms of the genesis of atrial fibrillation and?develops novel techniques for the monitoring of atrial tachycardia.?
Nominated as an outstanding Ph.D. thesis by the University of Manchester, UK Elucidates the mechanisms underlying atrial fibrillation May assist in the prevention and treatment of atrial fibrillation Provides detailed, multi-scale model of the heterogeneous human atria and torso Provides models of anatomically accurate and electrophysiologically detailed pacemaker struclãÃ