This essential volume explores mesenchymal stem cells (MSCs) and their potential to suppress immune-mediated inflammation. The chapters examine applications in autoimmune diseases such as lupus, rheumatoid arthritis and multiple sclerosis; blood cancers such as leukemia and lymphoma; and reproductive complications, specifically pre-term labor and use of MSCs in vitro and in animal models to discover methods of suppressing the causal inflammatory response. It also further defines the methodologies required to develop research on MSCs in vitro into established preclinical animal models including those which are proven replicas of autoimmunity and pre-term labor, to name but two.
Mesenchymal Stem Cells and Immunomodulation, part of Springers Stem Cell Biology and Regenerative Medicine, is an invaluable resource for researchers and clinicians working with stem cells, autoimmune disease, oncology, and reproductive medicine.
Overview.- Part I: Autoimmune Diseases.- Chapter 1: Altering Immune-Mediated Inflammatory Responses With Stem Cells.- Chapter 2: Rheumatoid Arthritis.- Chapter 3: Systemic Lupus Erythematosus.- Chapter 4: Crohns Diseases.- Chapter 5: Multiple Sclerosis.- Part II: Cancer.- Chapter 6: Eliminating Cancer with Stem Cells by Correcting Dysfunctional Immunity.- Chapter 7: Asymmetric Cell Division of Stem and Progenitor Cells in Homeostasis and Cancer.- Chapter 8: Stem Cells: Modifiers of Defective Transcription Factor Activity Induced by Cytokines in Cancer.- Chapter 9: Therapeutic Targeting of Prostate Cancer with Stem Cells.- Chapter 10: The Efficacy of Stem Cells in Experimental Animal Models of Leukemia.- Part III: Cardiovascular Disease.- Chapter 11: Immune-Mediated Inflammation in Heart Disease.- Chapter 12: Stem Cell Therapy: Dampening Immune-Mediated Inflammation in Coronary Artery Dil#,
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