Metabolic Syndrome: An Important Risk Factor for Stroke, Alzheimer Disease, and Depression [Hardcover]

Metabolic syndrome as an important risk factor for stroke, Alzheimer disease, and depression presents readers with cutting edge and comprehensive information on relationship among metabolic syndrome, stroke, Alzheimer disease, and depression. It is hoped that this monograph will be useful to postgraduate students, faculty, research scientists, pharmacologists, nutritionists, and physicians, who are curious about the molecular mechanisms that link metabolic syndrome with stroke, Alzheimer disease, and depression.???Chapter 1:The effect of unhealthy lifestyle on brain metabolism and function.- Chapter 2: The?effect of metabolic syndrome on the brain.- Chapter 3: The Association of essential fatty acid metabolism in the pathogenesis of metabolic syndrome and neurological disorders.- Chapter 4: Contribution of lipid mediators to the pathogenesis of metabolic syndrome and neurological disorders.- Chapter 5: Molecular aspects of obesity and insulin resistance in metabolic syndrome and neurological disorders.- Chapter 6: Dietary interventions of metabolic syndrome and neurological disorders.- Chapter 7: Signal transduction processes and metabolic link among metabolic syndrome and stroke.- Chapter 8: Signal transduction processes and metabolic link among metabolic syndrome and Alzheimers disease.- Chapter 9: Signal transduction processes and metabolic link among metabolic syndrome and depression.- Chapter 10: Future research?perspectives.

The metabolic syndrome is a cluster of common pathologies: abdominal obesity linked to an excess of visceral fat, insulin resistance, dyslipidemia and hypertension. At the molecular level, metabolic syndrome is accompanied not only by dysregulation in the expression of adipokines, cytokines, and chemokines but also by alterations in insulin and leptin signaling, oxidative stress, and chronic low grade inflammation. These changes affect immune responses and mediate chronic inflammation leading to alterations in the hypothalamilÓ*