Mitochondrial Biology and Experimental Therapeutics [Hardcover]

This book addresses the therapeutic strategies to target mitochondrial metabolism in diseases where the function of that organelle is compromised, and it discusses the effective strategies used to create mitochondrial-targeted agents that can become commercially available drug delivery platforms. The consistent growth of research focused in understanding the multifaceted role of mitochondria in cellular metabolism, controlling pathways related with cell death, and ionic/redox regulation has extended the research of mitochondrial chemical-biological interactions to include various pharmacological and toxicological applications. Not only does the book extensively cover basic mitochondrial physiology, but it also links the molecular interactions within these pathways to a variety of diseases. It is one of the first books to combine state-of-the-art reviews regarding basic mitochondrial biology, the role of mitochondrial alterations in different diseases, and the importance of that organelle as a target for pharmacological and non-pharmacological interventions to improve human health. The different chapters highlight the chemical-biological linkages of the mitochondria in context with drug development and clinical applications.

Target Mitochondria.- SECTION I-Mitochondrial Biology.- Introduction: Mitochondria: the cell furnace.- MItochondria: Where are They Coming From?.- Mitochondrial Dynamics: A journey from Mitochondrial Morphology to MItochondrial Function and Quality.- Mitochondrial ROS, Oxidative Stress.and Aging- The Mitochondrial Permeability Transition Pore.- Mitochondrial Regulation of Cell Death.- MItochondria in Liver Diseases.-  Mitochondria in Liver Regeneration,Energy Metabolism, and Posthepatectomy Liver Dysfunction.- MItochondrial Remodeling in Cancer.-  Mitochondria in Kidney Disease.- CNS diseases and disruption of Mitochondria.- Mitochondrial disruption in cardiovascular diseaseslÃ%