Molecular Basis of Membrane-Associated Diseases [Paperback]

Biological membranes are often effected by diseases. Molecular events leading to or arising from pathological changes in the course of different diseases are as yet not clearly understood. This competent study by leading experts covers changes of the cellular environment, membranes and the metabolic functions during tissue growth and differentiation as well as aspects of abnormal organelle function in lysosomal storage diseases, peroxisomal and mitochondrial disorders, enzyme defects and regulatory defects of receptors due to oncogenes.Biological membranes are often effected by diseases. Molecular events leading to or arising from pathological changes in the course of different diseases are as yet not clearly understood. This competent study by leading experts covers changes of the cellular environment, membranes and the metabolic functions during tissue growth and differentiation as well as aspects of abnormal organelle function in lysosomal storage diseases, peroxisomal and mitochondrial disorders, enzyme defects and regulatory defects of receptors due to oncogenes.1 Plasma Membrane and Control of Ce? Growth and Differentiation.- Insulin Receptor Kinase and Insulin Action.- Structural and Functional Aspects of Signal Transduction by Receptor Tyrosine Kinases.- Nerve Growth Factor (NGF): Physiological Functions and Regulation of Its Synthesis.- Signal Transduction by Growth Factor Receptors.- Altered Regulation of Receptor-Associated Tyrosine Kinases in Human Tumors.- The Role of Plasma Membrane Phospholipids in Cellular Pathology.- Changes in the Structure and Function of the Red Cell Membrane Skeleton and Hemolytic Anemias.- Regulation of Intracellular Ca2+ in Pancreatic Acinar Cells by Membrane Pumps and Channels.- Control of Protein Kinase C Function by Activators and Inhibitors.- 2 Regulation of Membrane Channels.- K+ Channels: Structure, Function, Regulation, Molecular Pharmacology and Role in Diseased States.- Voltage-Dependent Calcium Channels: Structure anl£