Molecular Basis and Thermodynamics of Bioelectrogenesis [Paperback]

Despite the fact that many years have elapsed since the first microcalorimetric measurements of an action potential were made, there is still among the research workers involved in the study of bioelectrogenesis a complete overlooking of the most fundamental principle governing any biological phenomenon at the molecular scale of dimension. This is surprising, the more so that the techniques of molecular biology are applied to characterize the proteins forming the ionic conducting sites in living membranes. For reasons that are still obscure to us the molecular aspects of bioelectrogenesis are completely out of the scope of the dynamic aspects of biochemistry. Even if it is sometimes recognized that an action potential is a free energy-consuming, entropy-producing process, the next question that should reasonably arise is never taken into consideration. There is indeed a complete evasion of the problem of biochemical energy coupling thus reducing the bioelectrogenesis to only physical interactions of membrane proteins with the electric field: the inbuilt postulate is that no molecular transformations, in the chemical sense, could be involved.I The Description in Physico-Chemical Terms of Nervous System Properties.- I.1. Living systems as dissipative structures with local quasi equilibrium.- I.2. Information flows in living systems.- I.3. Evolution of the ideas about bioelectrogenesis. A brief account.- References.- II Cell Membranes and Bioelectrogenesis.- II.1. The ubiquitous cellular component.- II.2. Membrane molecular components and their dynamics.- II.3. Silent and excitable membranes.- References.- III Phenomenological Aspects of Bioelectricity.- III.1. Resting potential of the cells.- III.2. The passive propagation of potential changes. Axons as electric cables.- III.3. Regenerative propagation of action potentials in excitable membranes.- III.4. Intercellular transmission of excitation.- III.5. An overview of bioelectric phenomena.- References.- IV Molecular lS-