Molecular and Cellular Aspects of Erythropoietin and Erythropoiesis [Paperback]

Molecular biology has provided a tool with which problems in cellular differentiation can be answered. Recombinant DNA technology has been used to obtain quantities of the erythropoietic hormone, erythropoietin. The availability of the hormone has provided a much-needed impetus in learning how erythropoiesis is controlled. Knowledge of the genetic components, transcription and translation of the erythropoietin gene and finally the release of the mature hormone under various physiological conditions should be forthcoming in the near future. This volume will give the reader some indication as to the different aspects of erythropoiesis. They include the regulation of production of the hormone under normal and abnormal conditions, ontogeny and cellular interactions and the assay of the hormone itself.Proceedings of the NATO Advanced Research Workshop on Mole- cular and Cellular Aspects of Erythropoiesis held in Bad Windsheim, FRG, September 1-4, 1986Molecular biology has provided a tool with which problems in cellular differentiation can be answered. Recombinant DNA technology has been used to obtain quantities of the erythropoietic hormone, erythropoietin. The availability of the hormone has provided a much-needed impetus in learning how erythropoiesis is controlled. Knowledge of the genetic components, transcription and translation of the erythropoietin gene and finally the release of the mature hormone under various physiological conditions should be forthcoming in the near future. This volume will give the reader some indication as to the different aspects of erythropoiesis. They include the regulation of production of the hormone under normal and abnormal conditions, ontogeny and cellular interactions and the assay of the hormone itself.Preface.- Acknowledgements.- Abbreviations.- Session 1 Molecular Biology of Erythropoiesis and Erythropoietin.- The Molecular Biology of Erythropoietin and the Expression of its Gene.- The Molecular Biology of Erythropoietin.- Analyl“B