Molecular Mechanisms of Neurodegenerative Diseases [Hardcover]

Ab Toxicity in Alzheimer's Disease, William L. Klein. Transgenic Models of Alzheimer's Disease, Michael C. Sugarman, Steven F. Hinton, and Frank M. LaFerla. Glial Cells in Alzheimer's Disease, Robert E. Mrak and W. Sue T. Griffin. Inflammation in Alzheimer's Disease, Caleb E. Finch, Valter Longo, Aya Miyao, Todd E. Morgan, Irina Rozovsky, Yubei Soong, Min Wei, Zhong Xie, and Hadi Zanjani. Proteolysis in Neurodegenerative Diseases, Vivian Y. H. Hook and Liane Mende-Mueller. Treatment Approaches for Alzheimer's Disease, Michael Gold, Kevin M. Felsenstein, and Perry Molinoff. Tau and a-Synuclein in Neurodegenerative Diseases, Benoit I. Giasson, Christina A. Wilson, John Q. Trojanowski, and Virginia M. Y. Lee. PET Investigations of Parkinson's Disease, Tamara Hershey, Stephen M. Moerlein, and Joel S. Perlmutter. Dopamine Neurotoxicity and Neurodegeneration, BethAnn McLaughlin. Mitochondria and Parkinson's Disease, Russell H. Swerdlow. Pathophysiology of SCA1, Harry T. Orr and Huda Y. Zoghbi. Pathophysiology of SCA3, Puneet Opal and Henry Paulson. Pathophysiology of Spinal and Bulbar Muscular Atrophy, Diane E. Merry. Mouse Models of Huntington's Disease, Marie-Fran?oise Chesselet and Michael S. Levine. Huntington-Associated Proteins, Marcy E. MacDonald, Lucius Passani, and Paige Hilditch-Maguire. Modeling Neurodegenerative Diseases in the Fruit Fly, George R. Jackson. Index. The reviews are well-written and well-edited so that they are accessible to both the researcher and non-researcher. The reviews examine a variety of current hypotheses as to the nature of neurodegeneration in a variety of conditions. . .This is a well-written book. Although no clear answers emerge, it shows the power of modern molecular methods in examining the underlying basis of these long baffling neurodegenerative disease. The practicing neurologist can only marvel at the power of the new molecular techniques that will soon reveal the underlying molecular basis of these disorders. This book clealSs