Molecular Neuropharmacology Strategies and Methods [Hardcover]

A powerful collection of readily reproducible cutting-edge techniques for characterizing the ligand or substrate binding of neurotransmitter receptors and transporters. The procedures cover interdisciplinary interactions for monoamine transporters, amino acid transporters, ionotropic receptors, metabotropic glutamate receptors, GABA receptors, and other G protein-coupled receptors. By illuminating how neurons in the central nervous communicate with other, these techniques can lead to the development of novel therapeutic strategies for neurological diseases.A powerful collection of readily reproducible cutting-edge techniques for characterizing the ligand or substrate binding of neurotransmitter receptors and transporters. The procedures cover interdisciplinary interactions for monoamine transporters, amino acid transporters, ionotropic receptors, metabotropic glutamate receptors, GABA receptors, and other G protein-coupled receptors. By illuminating how neurons in the central nervous communicate with other, these techniques can lead to the development of novel therapeutic strategies for neurological diseases.Part I. Molecular Pharmacology of Glutamate ReceptorsComputational Studies of Ligand-Receptor Interactions in Ionotropic Glutamate ReceptorsJeremy R. Greenwood and Tommy LiljeforsDelineation of the Physiological Role of Kainate Receptors by Use of Subtype Selective LigandsSari E. Lauri, Vernon R. J. Clarke, and Graham L. CollingridgeMolecular Pharmacology of the Metabotropic Glutamate ReceptorsAnders A. JensenPart II. Molecular Pharmacology of Gaba ReceptorsFunctional Characterization of GABAA Receptor Ligands In Vitro: Correlation With In Vivo ActivityBjarke Ebert, Sally Anne Thompson, Signe ? St?rustovu, and Keith A. WaffordIn Vivo Function of GABAA Receptor Subtypes Unraveled With Mutant MiceJean-Marc FritschyCharacterization of the GABAA Receptor Recognition Site Through Ligand Design and Pharmacophore ModelingBente Fr?land, Anne T. J?rgensen, Tommy Liljeforl“-