Monoclonal Antibodies in Cancer [Paperback]

1 Monoclonal Antibody Defined Antigens on Animal Tumors.- 1. Introduction.- 2. Antigen Expression on Chemically Induced Tumors.- 2.1. Murine Tumors.- 2.2. Rat Tumors.- 2.3. Guinea Pig Tumors.- 3. Use of Monoclonal Antibodies in Tumor Localization and Therapy.- 3.1. In Vivo Localization of Monoclonal Antibodies in Experimental Tumors.- 3.2. Serotherapy Using Antitumor Monoclonal Antibodies.- 3.3. Therapy Using Antitumor Monoclonal Antibodies Conjugated to Cytotoxic Agents.- 4. Conclusion.- References.- 2 Monoclonal Carcinoembryonic Antigen Antibodies.- 1. Introduction.- 2. The Development of Monoclonal CEA Immunoassays.- 2.1. General Concepts of Monoclonal Antibody Methodology.- 2.2. Experimental and Clinical Experience with Monoclonal CEA Antibodies.- 3. Monoclonal Antibodies in the Immunohistological Evaluation of CEA.- 4. Monoclonal Anti-CEA Antibodies in Tumor Imaging.- 5. Immunotherapy with Monoclonal CEA Antibodies.- 6. Summary.- References.- 3 Monoclonal Antibodies to Alphafetoprotein and Regulation of AFP Gene Expression.- 1. Introduction.- 2. Monoclonal Antibodies to AFP.- 2.1. ELISA Using Monoclonal Antibodies.- 2.2. Immune Localization Using Anti-AFP.- 2.3. Radioimmunescintigraphy.- 2.4. Immunotherapy.- 3. Control of AFP Gene Expression.- 3.1. AFP and Albumin Gene Expression During Development.- 3.2. AFP and Albumin Gene Structure.- 3.3. AFP and Albumin Gene Expression and Methylation.- 4. Summary.- References.- 4 Human Chorionic Gonadotropin Detection with Monoclonal Antibodies.- 1. Introduction: hCG Chemistry and Immunochemistry with Antisera.- 2. Description of Monoclonal Antibodies to hCG.- 2.1. Affinity, Isotype, Subclass, and Cross-Reactivity of Antibodies.- 2.2. Topological Mapping of Monoclonal Antibodies: Relative Orientation of Epitopes.- 2.3. Biological Effects of Monoclonal Antibodies Against hCG.- 2.4. Special Properties of Monoclonal Antibodies to hCG: Synergistic Effects.- 3. Immunoassays with Monoclonal Antibodies to hCG.- 3.1. Description l£j