Natriuretic Peptides in Health and Disease [Paperback]

A comprehensive, state-of-the-art review of the biochemistry, molecular and cellular biology, pharmacology, physiology, and pathology of natriuretic peptides. Written by the foremost researchers in the field, the reviews range from describing the actions of these peptides on the kidney, adrenal gland, vasculature, and brain, to their effects on immune regulation, reproduction, and cell growth. Special attention is given to the potential involvement of these hormones in clinical pathology and to their possible therapeutic use. Especially enlightening is the first-time review of molecular understanding of key cellular signaling pathways and of the importance of the vascular smooth muscle-endothelial interface.A comprehensive, state-of-the-art review of the biochemistry, molecular and cellular biology, pharmacology, physiology, and pathology of natriuretic peptides. Written by the foremost researchers in the field, the reviews range from describing the actions of these peptides on the kidney, adrenal gland, vasculature, and brain, to their effects on immune regulation, reproduction, and cell growth. Special attention is given to the potential involvement of these hormones in clinical pathology and to their possible therapeutic use. Especially enlightening is the first-time review of molecular understanding of key cellular signaling pathways and of the importance of the vascular smooth muscle-endothelial interface.The Biochemistry of Atrial Natriuretic Peptides, T. Geoffrey Flynn. The Guanylyl Cyclase-A Receptor, David C. Foster, David L. Garbers, and Barbara J. Wedel. The Guanylyl Cyclase-B Receptor, David G. Lowe. Molecular Determinants of Natriuretic Peptide Clearance Receptor Function, John A. Lewicki and Andrew A. Protter. Cellular and Molecular Aspects of the A-Type Natriuretic Peptide, David G. Gardner, Jianming Wu, and Branka Kovacic-Milivojevic. Cellular and Molecular Biology of B-Type Natriuretic Peptide, Christopher C. Glembotski. Cellular and Molecular Aspecl£‹