Neuroanatomy and Pathology of Sporadic Parkinson's Disease [Paperback]

The synucleinopathy sporadic Parkinsons disease (sPD) is the second most frequent degenerative disorder of the human nervous system after Alzheimers disease. The propensity for developing sPD exists in all ethnic groups worldwide, and the prevalence of the disorder increases considerably with age, thereby imposing an enormous social and economic burden on societies with increased life expectancy. The sPD-associated pathological process is progressive, does not go into remission, and can take decades to reach its culmination if it is not be terminated prematurely by death owing to other causes.

Against the background of the normal morphology and anatomy, the authors analyze the pathoanatomy of sPD in the nervous system at various neuropathological stages and summarize the potential functional consequences of the lesions.

Against the background of the normal morphology and anatomy, the authors of this text analyze the pathoanatomy of sPD in the nervous system at various neuropathological stages and summarize the potential functional consequences of the lesions.

Prologue.- Morphology of Lewy Pathology.- The Evolving Distribution Pattern of Lewy Pathology Associated with sPD Renders Neuropathological Staging Possible.- Stage 1.- Stage 2.- Stage 3.- Stage 4.- Stages 5 and 6.- The Progression of the Cortical Lesions Mimics the Pattern of Myelination in Reverse Order.- The Staging Hypothesis: Assumptions, Challenges, Potential.

The proteinopathy sporadic Parkinsons disease (sPD) is the second most frequent degenerative disorder of the human nervous system after Alzheimers disease. The a -synuclein inclusion body pathology (Lewy pathology) associated with sPD is distributed throughout the central, peripheral, and enteric nervous systems. The resulting nonrandom neuronal dysfunction and, in some regions, neuronal loss is reflected by a distinctive topographic distribution pattern of the Lewy pathology that, il£!