Neurodegenerative Diseases: Pathology, Mechanisms, and Potential Therapeutic Targets [Paperback]

Provides a timely overview of critical advances in molecular and cellular neurobiology, covers key methodologies driving progress, and highlights key future directions for research on neuronal injury and neurodegeneration relevant to neuronal brain pathologies. The editors bring together contributions from internationally recognized workers in the field to provide an up to date account of how and why molecular and cellular neurobiology is such an important area for clinical neuroscience. Understanding the molecular aspects of a number of neurodegenerative conditions such as Parkinson's or Alzheimer's disease for the purpose of improving patient management remains a major challenge of neurobiology be it from the basic or clinical perspective. A strategic evaluation of research contributions and the power of modern methods will help advance knowledge over the next years.Part 1: Major Neurodegenerative Conditions .- Alzheimers Disease  Insights from Genetic Mouse Models and Current Advances in Human IPSC-Derived Neurons.- Clinical Aspects of Alzheimers Disease.- Parkinsons Disease: Basic Pathomechanisms and a Clinical Overview.- Huntingtons Disease:  Pathogenic Mechanisms and Therapeutic Targets.- The Complexity of Clinical Huntingtons Disease: Developments in Molecular Genetics, Neuropathology and Neuroimaging Biomarkers.- Motoneurone Disease  Basic Science.- Motoneurone Disease  Clinical.- Multiple Sclerosis  Basic and Clinical.- Part 2: Other Neurological Conditions .- SchizophreniaBasic and Clinical.- Stroke  Basic and Clinical.- Epileptic Encephalopathies as Neurodegenerative Disorders.- Neurodegeneration and Pathology in EpilepsyClinical and Basic Perspectives.- Prion Disease  Basic and Clinical.- Leukodystrophies  Basic and Clinical.- Traumatic Brain Injury as a Trigger of Neurodegeneration.- Part 3: Key Background and Key Technologies.- Cell Death Mechanisms of Neurodegeneration.- Neuroglia: Functional ParalysislƒÒ