Novel Calcium-Binding Proteins Fundamentals and Clinical Implications [Paperback]

A wide variety of hormones, neurotransmitters and growth factors exert their cellular effects by reacting first with membrane receptors resulting in an increase of intracellular calcium and the cellular response. The calcium signal in the cell is mediated by the high-affinity calcium binding proteins (characterized by the EF-hand structural element), and by the calcium and phospholipid dependent proteins. Many of these have been discovered most recently. Their purification, distribution, protein and gene structures as well as their physiological roles are discussed. The book is of interest to biochemists and molecular biologists as well as to clinicians and the pharmaceutical industry who can apply the results in this field.A wide variety of hormones, neurotransmitters and growth factors exert their cellular effects by reacting first with membrane receptors resulting in an increase of intracellular calcium and the cellular response. The calcium signal in the cell is mediated by the high-affinity calcium binding proteins (characterized by the EF-hand structural element), and by the calcium and phospholipid dependent proteins. Many of these have been discovered most recently. Their purification, distribution, protein and gene structures as well as their physiological roles are discussed. The book is of interest to biochemists and molecular biologists as well as to clinicians and the pharmaceutical industry who can apply the results in this field.Preface.- Calcium-Binding Proteins: Past, Present, and Future.- Acknowledgments.- Section I Calcium Signaling by Calcium-Binding Proteins.- 1 The EF-Hand, Homologs and Analogs.- 2 Calcium-Binding Proteins of the EF-Hand-Type and of the Annexin Family: A Survey.- 3 Stains-All is a Dye that Probes the Conformational Features of Calcium Binding Proteins.- Section II EF-Hand Calcium-Binding Proteins: The S-100 Protein Family.- 4 The S-100 Protein Family: A Biochemical and Functional Overview.- 5 p9Ka, a Calcium-Ion-Binding Proteinl£"