N-Oxidation of Drugs Biochemistry, pharmacology, toxicology [Paperback]

One Analysis of N-Oxidized Products.- 1 Formation of aromatic amine free radicals by prostaglandin hydroperoxidase and peroxyl radicals: analysis by ESR and stable end products.- 1.1 Introduction.- 1.2 Metabolism of aromatic amines.- 1.3 Mechanism for the N-dealkylation of N-substituted amines.- 1.4 A new mechanism for the oxidation of amines.- 1.5 Conclusions.- References.- 2 The application of 15N-NMR in the analysis of N-oxygenated amidines and guanidines.- 2.1 Introduction.- 2.2 Technical aspects of measuring 15N-NMR spectra.- 2.3 Analysis of various classes of N-oxidized compounds.- 2.4 Conclusions.- References.- 3 Radioimmunoassay and other methods for trace analysis of N-oxide compounds.- 3.1 Introduction.- 3.2 Defining the problem.- 3.3 Techniques available for the qualitative and quantitative analysis of intact N-oxides.- 3.4 Conclusions.- References.- Two Enzymology of N-Oxidation.- 4 Mechanism, multiple forms and substrate specificities of flavincontaining mono-oxygenases.- 4.1 Introduction.- 4.2 Multiple forms.- 4.3 Mechanism.- 4.4 Specificity.- 4.5 Inhibitors.- References.- 5 On the genetic polymorphism of the flavin-containing monooxygenase.- 5.1 Introduction.- 5.2 Factors providing indirect evidence of the existence of multiple FMO forms.- 5.3 Factors providing direct evidence of the existence of multiple FMO forms.- 5.4 Conclusions.- References.- 6 Factors regulating the activity of the rabbit lung flavincontaining mono-oxygenase.- 6.1 Introduction.- 6.2 Purification and distinct properties of rabbit lung FMO.- 6.3 Regulation of maternal and fetal rabbit lung FMO during pregnancy.- 6.4 Diurnal regulation of rabbit FMO.- 6.5 Phospholipid binding to lung FMO and modulation of activity.- 6.6 Inhibition of FMO by tannic acid.- 6.7 Conclusions.- References.- 7 Human pharmacogenetics of nitrogen oxidations.- 7.1 Introduction.- 7.2 Human pharmacogenetics.- 7.3 Nitrogen oxidations.- 7.4 Primary trimethylaminuria: a pharmacogenetic phenomenon of nitrogen oxidlcª