The Nramp Family [Hardcover]

This book is the first comprehensive volume on the Nramp family , highlighting the physiological importance of Nramp proteins as metal transporters. The molecular knowledge of these membrane proteins is presented from an evolutionary perspective, considering Nramp cellular function and mechanism of transport in key model organisms. The pathological significance of Nramp genetic polymorphism is discussed with emphasis on metal homeostasis and microbial infection. The chapters were contributed by leading investigators, providing a timely state of the art book in this rapidly growing field.

The Nramp Family will be useful to a broad community of scientists interested in metal transport and molecular biology. It will be of interest to the research audience in the broad fields of metal ions and molecular medicine.

Preface. 1. Mouse Natural Resistance Associated Macrophage Protein 1 (Nramp1): A Key Player in Host Innate Immunity Against Infections; Nada Jabado, Steven Lam-Yuk-Tseung, John R. Forbes and Philippe Gros.

Why Mouse Models? Nramp1: A Mouse Host Resistance Locus.- Pathogens Under Nramp1 Control.- Nramp1 Gene and Protein Expression in Macrophages.- The Nramp Gene Family.- Divalent Cation Transport by Nramp Proteins.- Nramp1 Dependent Divalent Cations Transport

at the Phagosomal Membrane.- Structure/Function Studies by Site Directed Mutagenesis.- Divalent Cation Transport and Resistance to Infections.- Nramp1 and Phagosomal Maturation .

2. Genetic Susceptibility to Infectious Diseases Linked to NRAMP1 Gene in Farm Animals; Judith Caron, Danielle Malo, Christopher Schutta, Joe W. Templeton and L. Garry Adams.

Comparative Genomics.- Nramp1.- Chicken Genomics, Salmonella Infection and NRAMP1.- Bovine Genomics, Brucella abortus Infection and NRAMP1.

3. The NRAMP Genes and Human Susceptló#