Ocular Angiogenesis Diseases, Mechanisms, and Therapeutics [Hardcover]

Leading academic and pharmaceutical researchers and clinicians from many disciplines synthesize and summarize current clinical and basic knowledge concerning abnormal growth of blood vessels in the eye, the cause of major neovascular eye diseases. The authors also identify and assess the most promising approaches with potential for commercial exploitation and discuss the challenges encountered in developing therapeutics for ocular neovascular diseases. Highlights include illuminating chapters on gene therapy and novel drug delivery systems and excellent summaries of the newest therapeutic approaches.Leading academic and pharmaceutical researchers and clinicians from many disciplines synthesize and summarize current clinical and basic knowledge concerning abnormal growth of blood vessels in the eye, the cause of major neovascular eye diseases. The authors also identify and assess the most promising approaches with potential for commercial exploitation and discuss the challenges encountered in developing therapeutics for ocular neovascular diseases. Highlights include illuminating chapters on gene therapy and novel drug delivery systems and excellent summaries of the newest therapeutic approaches.I. Angiogenic DiseasesAge-Related Macular DegenerationCurtis L. Hagedorn and Ron A. AdelmanEndogenous Angiogenic Inhibitors in Diabetic RetinopathyJian-Xing Ma and Sarah X. ZhangCorneal AngiogenesisTrevor R. CarmichaelPolypoidal Choroidal VasculopathyNahoko Ogata and Kanji TakahashiMyopic Choroidal NeovascularizationKyoko Ohno-Matsui and Takashi TokoroMechanisms of the Formation and Stability of Retinal Blood VesselsJonathan Stone, Trent Sandercoe, and Jan ProvisNeovascular GlaucomaJames C. Tsai and M. Bruce ShieldsEales' DiseaseJyotirmay BiswasAngiogenesis and Ocular TumorigenesisNader Sheibani and Daniel M. AlbertGenetics of Ocular Vascular DiseaseJacquie Greenberg, Ari Ziskind, and Stephen P. DaigerII. Endogenous Promoters and Inhibitors of AngiogenesisVascular EndotheliallÂ