A well-designed experiment is an efficient method for learning about the physical world, however since experiments in any setting cannot avoid random error, statistical methods are essential for their design and implementation, and for the analysis of results. In this book, the fundamentals of optimum experimental design theory are presented. In the first part, the advantages of a statistical approach to the design of experiments are discussed, and the ideas of models, least squares fitting, and optimum experimental designs are introduced. The second part presents a more detailed discussion of the general theory of optimum design and an evaluation of various criteria that may be appropriate for designing experiments. Specific experiments are detailed and algorithms for the construction of designs are given. Each chapter is a self-contained, illustrated with examples drawn from science and engineering. Little previous statistical knowledge is assumed, and the derivation of mathematical results has been avoided. This book should be of interest to everyone concerned with designing experiments that are practical, efficient, and accurate.
PART I: Fundamentals 1. Introduction 2. Some Key Ideas 3. Experimental Strategies 4. The Choice of a Model 5. Models and Least Squares 6. Criteria for a Good Experiment 7. Standard Designs 8. The Analysis of Experiments PART II: Theory and Applications 9. Optimum Design Theory 10. Criteria of Optimality 11. D-Optimum Designs 12. Mixture Experiments 13. Experiments with Both Qualitative and Quantitative Factors 14. Blocking Response Surface Designs 15. Algorithms for the Construction of Exact D-Optimum Designs 16. Restricted Region Designs 17. Failure of the Experiment and Design Augmentation 18. Non-Linear Models 19. Optimum Bayesian Design 20. Discrimination between Models 21. Composite Design Criteria 22. Further Topics