Oral Treatment of Diabetes A Clinical and Experimental Review [Paperback]

Blood sugar lowering sulphonamide derivatives.- A. Thiodiazole derivatives.- I. Experiments.- II. Clinical experience with thiodiazole derivatives.- B. Sulphonylureas.- I. Constitution and activity.- a) Sulphonylureas.- b) N-sulphonyl-Nacylureas.- c) Sulplhoonylurethane.- d) 2-sulphonamido-1,3,4-thiodiazoles.- e) Sulphonylthioureas.- f) Ineffective sulphonylureas and their derivatives.- II. Animal experiments with BZ 55 and D 860.- a) Pharmacology and toxicity.- 1. Methods for determining in blood and urine.- 2. Absorption from the intestine.- 3. Distribution in the organism, tissue and protein bond.- 4. Degradation and excretion.- 5. Plasma level and blood sugar lowering (relationship of dose and effect).- 6. Bacteriostatic characteristics.- 7. Toxicity in animals.- ?) Acute toxicity.- ?) Chronic toxicity.- 8. Incompatibility and the influence of other drugs on the mode of action.- b) Mode of action.- 1. Research in vitro.- ?) Muscle tissue.- ?) Adipose tissue.- ?) Liver tissue.- ?) Insulinase system.- ?) Insulin aggregation in vitro.- ?) Respiratory activity of kidney slices and dopadecarboxylase.- 2. Effect in the eviscerated, decerebrated and diabetic animal.- ?) Eviscerated and decerebrated animal.- ?) Diabetes after total pancreatectomy.- ?) Alloxan diabetes.- ?) Pituitary and steroid diabetes.- ?) Starvation diabetes (Hungerdiabetes).- ?)Spontaneous canine diabetes and hereditary adiposity hyperglycaemia syndrome in the mouse.- 3. Influencing of ?-cells and the glucagon effect.- 4. ?-cells and insulin secretion.- ?) Morphological findings in the ?-cell system.- ?) Pancreatic insulin content.- ?) Activity of the plasma insulin and cross-circulation experiments.- ?) The action on various metabolic parameters influenced by insulin.- ?) Glucose tolerance.- ?)The mechanism of ?-cell influencing.- 5. The role of other endocrine organs.- ?) Thyroid.- ?) Supra-renals.- ?) Pituitary.- 6. The role played by the liver.- ?) Depression of the blood sugar in the hepateclƒ*