Organofluorine Compounds in Biology and Medicine [Hardcover]

Organofluorine Compounds in Biology and Medicine covers topics on biochemically relevant organofluorine compounds and their synthesis and biochemical pathways. Organofluorine compounds have renewed interest in pharmaceutical industry, and therefore a concise book on this topic is highly relevant to the scientific community involved in this area.

• Covers the synthesis, biochemical, and therapeutic applications of organofluorine compounds
• Offers a complete text on biochemically relevant organofluorine compounds and their synthesis and mechanistic pathways
• Provides one of the first major reference books on the biological and medicinal applications of organofluorine chemistry

1. Introduction: General aspects of organofluorine compounds 2. C-F bond strengths 3. Effect of the neighboring C-F bonds on the C-H bond dissociation energies 4. Effect of fluorine on the acidity and basicity 5. Effect of fluorine on the metabolic stability 6. Effect of fluorine on the bioavailability 7. Positron emission tomography (PET) tracers 8. 19F NMR Spectroscopic techniques for probing biochemical mechanisms 9. Summary and outlook

Covers the synthesis and biochemical and therapeutic applications of organofluorine compounds, making it an essential source for researchers interested in fluorine chemistry and its biomedical applications

Dr. Prakash Reddy is currently active in research and teaching at the Missouri University of Science and Technology. He has received his Ph.D. in organic chemistry from the Case Western Reserve University, Cleveland, Ohio, and M.Phil. from the University of Hyderabad, India. He was an Adjunct and Visiting Professor at nationally reputed universities prior to joining Missouri University of Science and Technology in 2000. He received the Golden Key National Honor Society award for teaching exlñ