This book covers all aspects of oxygen delivery to tissue, including blood flow and its regulation as well as oxygen metabolism. Special attention will be paid to methods of oxygen measurement in living tissue and application of these technologies to understanding physiological and biochemical basis for pathology related to tissue oxygenation. This book is multidisciplinary and designed to bring together experts and students from a range of research fields including biochemical engineering, physiology, microcirculation, and hematology.Part 1 Near Infrared SpectroscopyChapter 1The Western Reserve, Edward Morley and OxygenChapter 2Analysis of the Changes in the Oxidation of Brain Tissue Cytochrome c Oxidase in Traumatic Brain Injury Patients during Hypercapnoea: A Broadband NIRS StudyChapter 3Effects of Assuming Constant Optical Scattering on Haemoglobin Concentration Measurements using NIRS during a Valsalva ManoeuvreChapter 4Speech Therapy Changes Blood Circulation and Oxygenation in the Brain and Muscle. A Near-Infrared Spectrophotometry StudyPart 2 Oxygen Sensors and MeasurementChapter 5Evaluation of Lithium Naphthalocyanine (LiNc) Microcrystals for Biological EPR OximetryChapter 6Challenges to Intestinal pO2 Measurement Using EPRChapter 7Quantification of Systemic Interference in Optical Topography Data during Frontal Lobe and Motor Cortex Activation: An Independent Component AnalysisChapter 8Measuring Oxygen in Living Tissue: Intravascular, Interstitial and Tissue Oxygen MeasurementsChapter 9Cerebral Oxygenation of the Cortex and Striatum following Normobaric Hyperoxia and Mild Hypoxia in Rats by EPR Oximetry Using Multi-Probe Implantable ResonatorsChapter 1031P-MRS Studies of Melanoma Xenograft Metastatic PotentialChapter 11Modulation of Tumor Hypoxia by Topical Formulations with Vasodilators for Enhancing TherapyPart 3 Blood and Blood SubstitutesChapter 12MP4, A Vasodilatory PEGylated HemoglobinChapter 13Zymogen Protein C to Prevent Clotting Without Bl“!