Pancreatic Cancer [Hardcover]

Since the previous M.D. Anderson Solid Tumor Oncology Series publication on pancreatic cancer, there have been major advances in our understanding of molecular events which underlie pancreatic cancer development, both in the sporadic and inherited forms. This book provides information on the recent progress and improvements. It brings to the forefront the most current advances that have been made in understanding pancreatic cancer development and successfully treating this disease.

Since the previous M.D. Anderson Solid Tumor Oncology Series publication on pancreatic cancer, there have been major advances in our understanding of molecular events which underlie pancreatic cancer development, both in the sporadic and inherited forms. We have seen the development of the first mouse models that accurately recapitulate features of the human disease. Several landmark clinical trials in both resectable and metastatic pancreatic cancer have been completed, raising new questions about the standard of care in this disease. Finally, the era of targeted biologic therapies has engendered new excitement about the prospects of more rapid progress in understanding and successfully treating this dreadful disease. Therefore, it is an appropriate time to review these important advances and outline areas of controversy and question in pancreatic cancer biology and treatment.

Molecular Pathology and Epidemiology.- Spectrum of Human Pancreatic Neoplasia.- Molecular Genetics of Pancreatic Cancer.- Pancreatic Intraepithelial Neoplasia.- Pathology and Molecular Biology of Intraductal Papillary Mucinous Neoplasms.- Familial Pancreatic Cancer.- Hereditary Pancreatitis and Pancreatic Cancer.- Pancreatic Cancer Biology.- Pancreatic Progenitor Cells in Injury and Regeneration.- Development of the Endocrine and Exocrine Pancreas.- Models of Pancreatic Cancer: Understanding Disease Progression.- From Inception to Invasion: Modeling Pathways to Pancreatic Cancerlsh