PARP Inhibitors for Cancer Therapy [Paperback]

PARP Inhibitors for Cancer Therapy provides a comprehensive overview of the role of PARP in cancer therapy. The volume covers the history of the discovery of PARP (poly ADP ribose polymerase) and its role in DNA repair. In addition, a description of discovery of the PARP family, and other DNA maintenance-associated PARPs will also be discussed. The volume also features a section on accessible chemistry behind the development of inhibitors.

PARP inhibitors are a group of pharmacological inhibitors that are a particularly good target for cancer therapy. PARP plays a pivotal role in DNA repair and may contribute to the therapeutic resistance to DNA damaging agents used to treat cancer. Researchers have learned a tremendous amount about the biology of PARP and how tumour-specific defects in DNA repair can be exploited by PARPi. The synthetic lethality of PARPi is an exciting concept for cancer therapy and has led to a heightened activity in this area.

Section 1: What PARP is and What it Does????????????

1.?????? History of the discovery of poly (ADP-ribose)

Takashi Sugimura and Sydney Shall

2.?????? Discovery of the PARP superfamily and focus on the lesser exhibited but not lesser talented members

El?a H?berl?, Jean-Christophe Am?, Giuditta Illuzzi, Fran?oise Dantzer, Val?rie Schreiber

3.?????? The role of PARPs in DNA Strand Break Repair

Stuart L. Rulten, Fran?oise Dantzer and Keith W. Caldecott

4.?????? TIPs: Tankyrase Interacting Proteins

Susan Smith

5.?????? PARP and Carcinogenesis

Junhui Wang, Akira Sato, Hiroaki Fujimori, Yoshio Miki, Mitsuko Masutani

6.?????? Multitasking roles for poly(ADP-ribosyl)ation in aging and longevity

Section 2. NAD catalysis and thló¼