Pharmacokinetics for the Pharmaceutical Scientist [Paperback]

Major presentation of pharmacokinetics by a leading international expert. Methods for: estimating drug disposition parameters from data obtained after intravascular or extravascular drug administration, estimating rate and extent of drug bioavailability, and comparing rate and extent of drug availability following administration of several different dosage forms of a drug.Simple Linear Models More Complicated Linear Models Complicated Linear Models Linear Multicompartment Disposition Parameters from Extravascular Downslope C,T Data Noncompartmental and System Analysis Linear Multiple Dose Equations Simple Nonlinear Models More Complicated Nonlinear Models Urinary Excretion Absorption Analysis and Bioavailability Physiological Pharmacokinetics Relationship between Physiologically Based Flow Models and Usual Compartment Models Protein Binding Pharmacokinetic Pharmacodynamic Modelling Metabolic Kinetics Laplace Derivation of Linear Pharmacokinetic Equations Measures of Fit Appendix Index 175 Figures and Schematics, 51 Tables, 134 ReferencesA major presentation of pharmacokinetics by a leading international expert, this is a complete book on modeling the pharmacokinetics of drugs. It provides methods for: estimating drug disposition parameters from data obtained after intravascular or extravascular drug administration, estimating rate and extent of drug bioavailability, and comparing rate and extent of drug availability following administration of several different dosage forms of a drug. Authored by one of the founders of the field and written with insight that can only be obtained from years of experience, it is one of the very few advanced texts in the field. This is a very complete book on modeling the pharmacokinetics of drugs. . . It is one of the very few advanced texts in the field, written by one of the founders of the field and is written with a distilled insight that can only be obtained from years of experience in the field. I highly recommend it.
lS9