The Pharmacology of Psychotherapeutic Drugs [Paperback]

I. Phenothiazine Derivatives.- A. Structure-activity Relationships.- B. Peripheral Effects.- 1. Adrenolytic, Cholinolytic, Antihistaminic and Anti-serotonin Effects.- 2. Effects on Heart, Circulation and Vasculature.- 3. Muscle Relaxant Effect.- 4. Miscellaneous Effects.- C. Central Effects.- 1. Effects on the Spinal Cord.- 2. Influence on Medullary, Mesencephalic and Diencephalic Autonomic Functions.- a) Antiemetic Effect.- b) Influence on Central Mechanisms Governing Circulation.- c) Effects on Body Temperature.- d) Effect on Appetite.- e) Influence on Central Sympathetic Mechanisms.- 3. Influence on Bioelectrical Phenomena in the CNS.- a) Changes in the EEG.- b) Effect on EEG Arousal Reaction.- c) Influence on the Electrical Activity of the Reticular Formation.- d) Influence on Thalamic Projection System.- e) Effect on the Limbic System.- f) Effects on the Cortex.- g) Interpretation of Electrophysiological Effects.- 4. Results from Behavioral Investigations.- a) Influence on General Behavior.- b) Effect on Operant Conditioned Behavior.- 5. Biochemical Effects on the CNS.- a) Influence on Respiration, Oxidative Phosphorylation, Phospholipid Metabolism and Various Enzymes.- b) Acetylcholine Metabolism.- c) Norepinephrine, Dopamine and 5-HT Metabolism.- 6. Extrapyramidal Motor Disturbances in Man and Catalepsy in Animals.- a) Extrapyramidal Motor Disturbances in Man.- b) Catalepsy in Animals.- c) Biochemical Considerations of Phenothiazine Effects on the Extrapyramidal System.- 7. Interaction of Phenothiazines with other Centrally Acting Agents.- a) General Anesthetics and Hypnotics.- b) Central Stimulants, Convulsants, Physostigmine.- c) Influence on Central Effects of Morphine.- D. Endocrine Effects.- E. Metabolic Fate of Phenothiazines.- F. Habituation and Withdrawal.- G. Adverse Reactions and Treatment Risks.- 1. Suicide and Fatal Poisoning.- 2. Central Nervous System.- 3. Autonomic Nervous System.- 4. Striated Musculature.- 5. Jaundice.- 6. Agranulocytosis.- 7.lP